Breast cancer risk: Data about the relation with breast cancer risk was provided by a pooled analysis of 5 cohorts (15), and 2 additional cohorts (25, 26).
No significant effects were found.
Breast cancer mortality: No data was found.
Conclusion: No effects were found. No evidence was found for an association between broccoli and breast cancer.
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments |
| 26) Adebamowo CA. (2005) | The Nurses Health Study II. | 90,630 premenopausal women aged 26-46. (USA) | 8 (1991-1999) | 710 | Invasive breast cancer risk | Broccoli |
RR = 0.99 (0.59-1.65; P = 0.10) for the highest vs lowest quintile of consumption. Amount specific data (servings): < 1/month: RR = 1. 1-3/month: RR = 1.31 (0.88-1.95). 1/week: RR = 1.32 (0.90-1.94). 2-4/week: RR = 1.15 (0.77-1.70). ≥ 5/week: RR = 0.99 (0.59-1.65). No association was found between flavonol-rich foods and the risk of breast cancer characterized by either estrogen or progestone receptor status or within strata of smoking status (data not shown). | age at menarche, parity and age at first birth, family history of breast cancer in mother and/or sister, history of benign breast disease, oral contraceptive use, alcohol, energy, BMI, height, smoking habit, physical activity, and menopausal status. |
| 25) Wang L (2009) | The Women's Health Study | 38,408 female health professionals aged ≥ 45. (USA) | 11.5 (1992-95 to 2007) | 1,351? | Breast cancer incidence | Broccoli | Risk did not materially change with intake (data not shown). | Age, race, total energy, randomized treatment assignment, smoking, alcohol use, physical activity, postmenopausal status, hormone replacement therapy use, multivitamin use, family history of colorectal cancer, ovary cancer, or breast cancer, and intake of fruit and vegetables, fiber, folate, and saturated fat. |
| 15) Smith-Warner SA. (2001) | Pooled Analysis of 5 Cohort Studies. | 212,770 | 5-16 | 4,962? | Invasive breast cancer risk | Broccoli |
INCLUSION CRITERIA:
RELATIVE RISK: No significant association: RR = 0.86 (0.72-1.02) per 100 g/day increment. P for heterogeneity in results across studies = > 0.99. Menopausal status at follow-up did not modify the associations (no data shown). | Age at menarche, interaction between parity and age at birth of first child, oral contraceptive use (ever/never), history of benign breast disease, menopausal status at follow-up, postmenopausal hormone use, family history of breast cancer, smoking status (ever/never), education, BMI, BMI-menopausal status interaction, height, alcohol intake, and energy intake. |