| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments |
| 36) Iso H (2007) | The JACC Study. | 56,195 women. (Japan) | Not defined. | 90 | Breast cancer mortality | Fruits other than citrus fruits (not defined) |
HR = 1.36 (0.78-2.37) for the highest vs lowest tertile of consumption.
Amount specific data:
< 3/w: HR = 1.
3-4/w: HR = 0.87 (0.42-1.77).
≥ 5/w: HR = 1.36 (0.78-2.37).
| Age and study area. |
| 21) Olsen A (2003) | The Diet, Cancer and Health Cohort | 23,798 postmenopausal women age 50-64. (Denmark) | 1993-97 to 2000 | 425? | Breast cancer risk | Fruit porridge | No single subgroup of fruits and/or vegetables was strongly associated with the incidence rate of breast cancer in this study (no data shown). | Age, time under study, parity, previous benign breast tumor surgery, education, use of hormone replacement therapy, duration of HRT use, intake of alcohol and BMI. |
| 21) Olsen A (2003) | The Diet, Cancer and Health Cohort | 23,798 postmenopausal women age 50-64. (Denmark) | 1993-97 to 2000 | 425? | Breast cancer risk | Preserved fruit | No single subgroup of fruits and/or vegetables was strongly associated with the incidence rate of breast cancer in this study (no data shown). | Age, time under study, parity, previous benign breast tumor surgery, education, use of hormone replacement therapy, duration of HRT use, intake of alcohol and BMI. |
| 21) Olsen A (2003) | The Diet, Cancer and Health Cohort | 23,798 postmenopausal women age 50-64. (Denmark) | 1993-97 to 2000 | 425? | Breast cancer risk | Stalk vegetables (not defined, but including leek) | No single subgroup of fruits and/or vegetables was strongly associated with the incidence rate of breast cancer in this study (no data shown). | Age, time under study, parity, previous benign breast tumor surgery, education, use of hormone replacement therapy, duration of HRT use, intake of alcohol and BMI. |
| 15) Smith-Warner SA. (2001) | Pooled Analysis of 5 Cohort Studies. | 212,770 | 5-16 | 4,962? | Invasive breast cancer risk | Peaches, apricots, plums, nectarines |
INCLUSION CRITERIA:
- 1) A published prospective study with at least 200 incident breast cancer cases.
- 2) Assessment of usual dietary intake.
- 3) A validation study of the diet assessment method or a closely related instrument.
INCLUDED STUDIES (Follow-up years/No. of breast cancer cases):
- The Canadian National Breast Screening Study (1982-1987/419).
Rohan TE, Howe GR, Friedenreich CM, Jain M, Miller AB. Dietary fiber, vitamins A, C, and E, and risk of breast cancer: a cohort study. Cancer Causes Control. 1993 Jan;4(1):29-37. Abstract
- The Iowa Women's Health Study (1986-1995/1130).
Kushi LH, Fee RM, Sellers TA, Zheng W, Folsom AR. Intake of vitamins A, C, and E and postmenopausal breast cancer. The Iowa Women's Health Study. Am J Epidemiol. 1996 Jul 15;144(2):165-74. Full text
- The New York State Cohort (1980-1987/367).
Graham S, Zielezny M, Marshall J, Priore R, Freudenheim J, Brasure J. Diet in the epidemiology of postmenopausal breast cancer in the New York State Cohort. Am J Epidemiol. 1992 Dec 1;136(11):1327-37. Abstract
- The New York University Women's Health Study (1985-1994/386).
Toniolo P, Riboli E, Shore RE, Pasternacks BS. Consumption of meat, animal products, protein, and fat and risk of breast cancer: a prospective cohort study in New York. Epidemiology. 1994 Jul;5(4):391-7. Abstract
- The Nurses' Health Study A + B (A = 1980-1986/1023. B = 1986-1996/1638).
Zhang S, Hunter DJ, Forman MR, Rosner BA, Speizer FE, Colditz GA. Dietary carotenoids and vitamins A, C, and E and risk of breast cancer. J Natl Cancer Inst. 1999 Mar 17;91(6):547-56. Full text
RELATIVE RISK:
No significant association: RR = 1.00 (0.91-1.09) per 100 g/day increment.
P for heterogeneity in results across studies = 0.59.
Menopausal status at follow-up did not modify the associations (no data shown).
| Age at menarche, interaction between parity and age at birth of first child, oral contraceptive use (ever/never), history of benign breast disease, menopausal status at follow-up, postmenopausal hormone use, family history of breast cancer, smoking status (ever/never), education, BMI, BMI-menopausal status interaction, height, alcohol intake, and energy intake. |
| 13) Key TJ (1999) | The Hiroshima/Nagasaki Life Span Study. | 34,759 women. (Japan) | 1969-70 and/or 1979-81 to 1993 | 396 | Breast cancer incidence | Sea vegetables (not defined) |
RR = 0.89 (0.69-1.16; P = 0.417) for the highest vs lowest tertile of consumption.
Amount specific data (Frequency of consumption):
≤ 1/week: RR = 1.
2-4/week: RR = 0.88 (0.70-1.11).
≥ 5/week: RR = 0.89 (0.69-1.16). | Age, calendar period, city, age at time of bombing and radiation dose. |
| 5) Rohan TE. (1993) | The Canadian National Breast Screening Study. | 56,837 women. (Nested case-control study) | 1982-1987 | 518 | Breast cancer risk | Vegetables rich in vitamins A and C (not defined) |
OR = 0.74 (0.52-1.05; P = 0.086) for the highest vs lowest quintile of consumption.
Amount specific data (g/day):
< 45: OR = 1.
45-73: OR = 0.85 (0.60-1.19).
73-108: OR = 1.03 (0.74-1.43).
108-169: OR = 0.81 (0.57-1.14).
> 169: OR = 0.74 (0.52-1.05). | Age, age at menarche, surgical menopause, age at first livebirth, years of education, family history of breast cancer, history of benign breast disease, and other contributors to total food intake. |
| 4) Fung TT (2006) | The Nurses' Health Study. | 71,058 women. | 18 (1984-2002) | 575 | ER- Breast cancer incidence | Other vegetables (corn, mixed vegetables, eggplant, celery, green peppers, onions) |
RR = 0.67 (0.53-0.87; P = 0.03) for the highest vs lowest quartile of consumption.
Amount specific data:
< 2/wk: RR = 1.
2-4/wk: RR = 0.94 (0.76-1.15).
5-6/wk: RR = 0.69 (0.51-0.92).
1+/d: RR = 0.67 (0.53-0.87). After additional adjustment for other vegetables, the RR became: 0.73 (0.54-0.99; P = 0.26). | Energy intake, smoking, BMI, alcohol, weight change since age 18 y, menopausal status and postmenopausal hormone use, BMI at age 18 y, family history of breast cancer, history of benign breast disease, physical activity, multivitamin supplement use. |