Eggs & cardiovascular disease (CVD).
2 articles, providing information about 2 different cohorts were found. In both cases the association with disease risk was examined.
Results: Results about subjects without prevalent disease were restricted to one cohort of very small size (Houston DK). No association was found.
In both cohorts, results were shown about subjects with pre-existing type 2 diabetes (Houston DK; Tanasescu M). A significantly increased risk was found in both
cohorts, including 664 cases.
Effect modification: No data was found.
Conclusion: Significantly increased risk were found in both cohorts among subjects with type 2 diabetes. One cohort was of very small size. Suggestive evidence was found for an increased CVD risk of egg consumption among subjects with type 2 diabetes (+ 68%).
| Author | Cohort name | Cases | Relative Risk (RR) |
|---|---|---|---|
| 18) Houston DK (2010) | The Health ABC Study | 45 | HR = 5.02 (1.63-15.52; P = 0.005). |
| 8) Tanasescu M (2004) | The Nurses' Health Study | 619 | RR = 1.44 (1.05-1.98; P = < 0.001). |
| Total number of cases: 664 | Average RR = 1.68 |
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments | |||||||||||||
| 18) Houston DK (2010) | The Health ABC Study | 1,941 black and white men and women aged 70-79 without prevalent CVD. (USA) | 9 (1999-?) | 203 | CVD incidence (nonfatal MI, coronary death, or stroke) | Eggs (including biscuit sandwiches, and egg McMuffins) |
HR = 1.68 (1.12-2.51; P = 0.01) for the highest vs lowest tertile of consumption (3+ vs < 1 eggs/week). This association remained after additional adjustment for other breakfast foods hign in fat (e.g., sausage or bacon; P = < 0.05).
Age, gender, race, education, field center, smoking, alcohol use, physical activity, BMI, total energy intake, protein intake, fiber intake, multivitamin use, supplemental vitamin E use, statin use, aspirin use, oral estrogen use (women only), prevalent diabetes or hypertension, and saturated fat. |
8) Tanasescu M (2004) | The Nurses' Health Study | 5,672 women with type 2 diabetes, but without CVD or cancer. | 1980 to 1994-98 | 619? | CVD events (nonfatal myocardial infarction, fatal coronary heart disease, and stroke) | Eggs |
RR = 1.44 (1.05-1.98; P = < 0.001) for the highest vs lowest quintile of consumption. | Amount specific data (eggs/wk): < 1: RR = 1. 1-< 3: RR = 1.10. 3: RR = 1.08. 3-6: RR = 1.39. > 6: RR = 1.44 (1.05-1.98). Age, smoking, postmenopausal hormone use, parental history of MI before age 60, alcohol intake, moderate vigorous activities, BMI, total caloric intake, protein intake, fiber intake, multivitamin use, vitamin E supplement use, and medication use. |
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