Eggs & heart failure.
2 articles, providing information about 2 different cohorts were found, including 2,224 cases.
Results: Significantly increased risks were found in both cohorts. In one cohort, the trend but not the effect was significant (Djoussé L).
Effect modification: No significant interactions were found with diabetes (Nettleton JA; Djoussé L), hypertension
(Nettleton JA; Djoussé L), baseline CVD/BMI/sex/race/dietary variables (Nettleton JA), or hypercholesterolemia/smoking (Djoussé L).
Conclusion: Significantly increased risks were found in 2 cohorts of small-moderate size. Suggestive evidence was found for an increased heart failure
risk of high egg consumption (+ 39%).
| Author | Cohort name | Cases | Relative Risk (RR) |
|---|---|---|---|
| 17) Djoussé L (2008) | The Physician's Health Study | 1,084 | RR = 1.56 (0.99-2.46; P = 0.006). |
| 16) Nettleton JA (2008) | The ARIC Study | 1,140 | RR = 1.23 (1.08-1.41; P = < 0.05). |
| Total number of cases: 2,224 | Average RR = 1.39 |
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments | |||||||||||||
| 17) Djoussé L (2008) | The Physician's Health Study I. | 21,275 men. (USA) | 20.4 | 1,084 (911 without antecedent myocardial infarction) | Risk of heart failure | Eggs |
There was no evidence for 2-way interaction between egg consumption and diabetes mellitus (P = 0.27), history of hypertension (P = 0.97), smoking (P = 0.70), or hypercholesterolemia (P = 0.85). Age, BMI, smoking, alcohol consumption, physical activity, history of valvular heart disease and treatment for cholesterol, and history of diabetes mellitus, atrial fibrillation, and hypertension. |
16) Nettleton JA (2008) | The Atherosclerosis Risk In Communities (ARIC) Study. | 14,153 African-American and white adults age 45-64. | (USA) 13.3 | (1987-89 to 2003) 1,140? (639 men, 501 women) | Incident heart failure | Eggs (boiled, poached, fried, scrambled, omelets, egg salad, quich, not including egg substitutes) | RR = 1.23 (1.08-1.41; P = < 0.05) for a 1 serving/d difference. | This association remained after adjusting for other food groups (whole grains; fruits and vegetables; high-fat dairy; red meat or processed meat; fish; nuts): RR = 1.23 (1.07-1.42). There were no significant interactions between dietary intake variables and BMI, sex, race, or baseline disease status (CVD, diabetes, or hypertension) (data not shown). Energy intake, age, sex, race/center, education level, physical activity level, smoking status, drinking status, and prevalent disease (cardiovascular disease, diabetes, and hypertension). |
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