Eggs & stroke.
Eggs and stroke risk.
5 articles, providing information about 4 different cohorts were found, including 2,818 cases.
Results: No (non)significant association was found between eggs and total stroke risk in any cohort at any level of consumption. In addition, no
significant associations were found with ischemic or hemorrhagic stroke at any level of consumption.
Effect modification: No significant differences in effect were found in subgroups defined by serum cholesterol (Qureshi AI; Djoussé L),
systolic blood pressure (Qureshi AI), or cigarette smoking (Qureshi AI). And no significant associations were found among subjects with pre-existing
diabetes mellitus (Qureshi AI; Djoussé L).
Conclusion: No associations were found. No evidence was found for an association between any level of egg consumption and stroke risk (Average RR = 0.95).
| Author | Cohort name | Cases | Relative Risk (RR) |
|---|---|---|---|
| 17) Djoussé L (2008) | The Physician's Health Study | 1,342 | HR = 0.99 (0.80-1.23; P = 0.40). |
| 14) Qureshi AI (2007) | The NHANES I | 655 | RR = 0.9 (0.7-1.1). |
| 8) Hu FB (1999) | The Health Professional's Follow-up Study, and The Nurses' Health Study | 258 men, and 563 women | Men: RR = 1.00 (0.57-1.78; P = 0.95). Women: RR = 0.89 (0.60-1.31; P = 0.77). |
| Total number of cases: 2,818 | Average RR = 0.95 |
Eggs and stroke mortality.
4 articles, providing information about 4 different cohorts were found, including 3,978 cases.
Results: Significant protective effects of high vs low consumption were found in 2 cohorts. In one cohort the effect but not the trend was significant (Sauvaget C),
and in the other cohort the effect was restricted to women only (Iso H). The effects were found at the level of consumption of ≥ 5 eggs/week.
In another cohort a significantly increased risk was found at an intermediate level of consumption (0.5 egg/day) among women only (Nakamura Y).
Effect modification: No data was found.
Conclusion: Results were restricted to Asian populations. Though protective effects of high vs low consumption were found in 2 cohort of moderate-large size, the effect was once restricted to women only. Inconclusive evidence was found for an association between egg consumption and stroke death (excluding incomplete data from Ross RK [6]: Average RR = 0.84).
| Author | Cohort name | Cases | Relative Risk (RR) |
|---|---|---|---|
| 15) Iso H (2007) | The JACC Study | 1,225 men, and 1,030 women | Men: HR = 0.99 (0.86-1.14). Women: HR = 0.84 (0.72-0.97; P = < 0.05). |
| 10) Nakamura Y (2004) | The NIPPON DATA80 | 112 men, and 107 women | Men:RR = 0.25 (0.03-1.81; P = 0.11). Women: RR = 1.22 (0.29-5.17; P = 0.23). |
| 9) Sauvaget C (2003) | The Hiroshima/Nagasaki Life Span Study | 1,259 | HR = 0.70 (0.51-0.95; P = 0.185). |
| 6) Ross RK (1997) | No cohort name | 245 | No significant association. |
| Total number of cases: 3,978 | Average RR = 0.84 |
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 17) Djoussé L (2008) | The Physician's Health Study I. | 21,327 male physicians aged 40-85.(USA) | 20 | 1,342 | Stroke incidence | Eggs |
HR = 0.99 (0.80-1.23; P = 0.40) for the highest vs lowest quintile of consumption. Amount specific data (Eggs/week): < 1: RR = 1. 1/wk: HR = 0.96 (0.82-1.13). 2-4/wk: HR = 1.06 (0.91-1.24). 5-6/wk: HR = 1.13 (0.89-1.42). ≥ 7/wk: HR = 0.99 (0.80-1.23).
A history of hypercholesterolemia at baseline did not influence the relation between egg consumption and stroke (data not shown). BMI, smoking, history of hypertension, multivitamin intake, alcohol consumption, vegetable consumption, breakfast cereal, physical activity, treatment arm, atrial fibrillation, diabetes mellitus, hypercholesterolemia, and parental history of premature myocardial infarction. |
14) Qureshi AI (2007) | The NHANES I | 9,734 adults aged 25-74 and without a history of stroke or MI. | (USA) 1971-75 to 1982-92 | See variables | All stroke risk (hospitalization or death due to ischemic and hemorrhagic events, but excluding transient ischemic events) | Eggs (eggs eaten as in the form of fried, boiled, poached, deviled, or egg salad. Excluding eggs in cooked or baked dished, as custards, puddings) |
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No significantly different risk was observed associated with daily egg consumption in subgroups defined by systolic blood pressure, serum cholesterol, and cigarette smoking. Age, gender, race/ethnicity, systolic blood pressure, diabetes mellitus, serum cholesterol, cigarette smoking, BMI, and educational status. |
14) Qureshi AI (2007) | The NHANES I | 9,734 adults aged 25-74 and without a history of stroke or MI. | (USA) 1971-75 to 1982-92 | See variables | Ischemic stroke risk | Eggs (eggs eaten as in the form of fried, boiled, poached, deviled, or egg salad. Excluding eggs in cooked or baked dished, as custards, puddings) |
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No significantly different risk was observed associated with daily egg consumption in subgroups defined by systolic blood pressure, serum cholesterol, and cigarette smoking. Age, gender, race/ethnicity, systolic blood pressure, diabetes mellitus, serum cholesterol, cigarette smoking, BMI, and educational status. |
8) He K. (2003) | The Health Professionals Follow Up Study. | 43,732 men aged 40-75. | (USA) 14 | (1986-2000) 448 ischaemic stroke, and | 121 haemorrhagic stroke Stroke risk | Eggs |
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Age, smoking, BMI, physical activity, history of hypertension, smoking status, aspirin use, multivitamin use, and consumption of alcohol, potassium, fibre, vitamin E, total servings of fruit and vegetables, total energy, and hypercholesterolaemia. |
8) Iso H. (2001) | The Nurses' Health Study. | 85,764 women aged 34-59. | (USA) 14 | (1980-1994) 74? | Intraparenchymal hemmorhage risk | Eggs | A significant inverse association (No data shown). | Age, smoking status, time interval, BMI, alcohol intake, menopausal status and postmenopausal hormone use, vigorous exercise, usual aspirin use, multivitamin use, vitamin E use, n3 fatty acid intake, calcium intake, and histories of hypertension, diabetes, and high cholesterol levels, and total energy. |
8) Hu FB. (1999) | The Health Professionals Follow-up Study & | The Nurses' Health Study. 37,851 men aged 40-75, and 80,082 women aged 34-59. | HPFS: 1986-1994. | NHS: 1980-1994. Total stroke: 258 men, and 563 women. | Ischemic stroke: 166 men, and 296 women. Hemmorhagic stroke: 52 men, and 176 women. Stroke incidence | Eggs (Including in other foods such as cakes, cookies, pancakes, muffins, sweet rolls, and donuts) |
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Age, BMI, 2-year time periods, cigarette smoking, parental history of myocardial infarction, multivitamin supplement use, vitamin E supplement use, alcohol consumption, menopausal status and postmenopausal hormone use, history of hypertension, physical activity, and total energy intake. |
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