Fish roe and cardiovascular disease.

Data about fish roe was provided by 2 cohorts. Fish roe intake was examined in one cohort (Myint PK [34]), and salted fish roe intake was examined in the other cohort (Takachi R [33]). A positive association with total cardiovascular disease was found among women in one cohort (33). But no significant associations were found with coronary heart disease (33), or stroke (33, 34).

Conclusion: Inconclusive evidence was found for an association between fish roe intake and cardiovascular disease.

**Prospective studies of fish roe consumption and total cardiovascular disease:**
Author	Cohort name	Subjects	Years of follow-up	Cases	End point	Consumption of	Relative Risk (RR)	Adjustments
33) Takachi R (2010)	The JPHC Study	77,500 subjects (35,730 men and 41,770 women) aged 45-74, and without a history of cancer, CHD, or stroke. (Japan)	1995-98 to 2004	2,066	Cardiovascular disease risk	Salted fish roe (tarako [salted Alaska pollack roe] or suziko [salted salmon roe]; 4.6-4.8% salt)	HR = 1.08 (0.93-1.25; P = 0.27) for the highest vs lowest quintile of consumption. Amount specific data (g): 0.0: HR = 1. 0.2: HR = 1.02 (0.86-1.21). 0.7: HR = 1.00 (0.86-1.17). 1.6: HR = 1.00 (0.85-1.17). 4.7: HR = 1.08 (0.93-1.25). Effect modification: A positive association was found among women (no data shown). No significant interaction was found with smoking status, age, cohort (I or II), BMI, or alcohol intake (no data shown).	Sex, age, BMI, smoking status, alcohol, physical activity, and energy, potassium, and calcium.

**Prospective studies of fish roe consumption and coronary heart disease:**
Author	Cohort name	Subjects	Years of follow-up	Cases	End point	Consumption of	Relative Risk (RR)	Adjustments
33) Takachi R (2010)	The JPHC Study	77,500 subjects (35,730 men and 41,770 women) aged 45-74, and without a history of cancer, CHD, or stroke. (Japan)	1995-98 to 2004	338	Myocardial infarcion risk	Salted fish roe (tarako [salted Alaska pollack roe] or suziko [salted salmon roe]; 4.6-4.8% salt)	HR = 0.80 (0.55-1.16; P = 0.21) for the highest vs lowest quintile of consumption. Amount specific data (g): 0.0: HR = 1. 0.2: HR = 0.95 (0.63-1.43). 0.7: HR = 0.85 (0.58-1.23). 1.6: HR = 0.63 (0.42-0.95). 4.7: HR = 0.80 (0.55-1.16). Effect modification: No significant interaction was found with sex, smoking status, age, cohort (I or II), BMI, or alcohol intake (no data shown).	Sex, age, BMI, smoking status, alcohol, physical activity, and energy, potassium, and calcium.

Prospective studies of fish roe consumption and stroke:

Author

Cohort name

Subjects

Years of follow-up

Cases

End point

Consumption of

Relative Risk (RR)

Adjustments

34) Myint PK (2006)

The EPIC-Norfolk Study

24,312 subjects (10,972 men and 13,340 women) aged 40-79, and without stroke.
(UK)

8.5
(1993-97 to 2004)

217 men, and 204 women

Stroke incidence (mortality and hospital episodes)

Fish roe (fish roe and taramasalata)


Men	Women
RR = 1.13 (0.63-2.03; P = 0.69) for consumption vs no consumption.	RR = 1.34 (0.74-2.41; P = 0.34) for consumption vs no consumption.

Age, systolic blood pressure, BMI, smoking, cholesterol, diabetes, fish oil supplements, physical activity, alcohol consumption and total energy intake.

33) Takachi R (2010)

The JPHC Study

77,500 subjects (35,730 men and 41,770 women) aged 45-74, and without a history of cancer, CHD, or stroke.
(Japan)

1995-98 to 2004

1,745

Stroke risk

Salted fish roe (tarako [salted Alaska pollack roe] or suziko [salted salmon roe]; 4.6-4.8% salt)

HR = 1.14 (0.97-1.34; P = 0.09) for the highest vs lowest quintile of consumption.

Amount specific data (g):
0.0: HR = 1.
0.2: HR = 1.05 (0.87-1.27).
0.7: HR = 1.02 (0.86-1.21).
1.6: HR = 1.08 (0.91-1.28).
4.7: HR = 1.14 (0.97-1.34).

Effect modification:
No significant interaction was found with sex, smoking status, age, cohort (I or II), BMI, or alcohol intake (no data shown).

Sex, age, BMI, smoking status, alcohol, physical activity, and energy, potassium, and calcium.

Cardiovascular disease & Diet. A systematic review.

Literature review.

Relating various aspects of our
diet to heart disease and stroke.

Fish roe and cardiovascular disease.

Cardiovascular disease & Diet. A systematic review.

Literature review.

Relating various aspects of ourdiet to heart disease and stroke.

Fish roe and cardiovascular disease.

Relating various aspects of our
diet to heart disease and stroke.