Consumption of total dietary omega 6 fatty acids and cardiovascular disease.

Total omega 6 fatty acids and total cardiovascular disease (CVD).

No data was found.

Total omega 6 fatty acids and coronary heart disease (CHD).

Results: Data was provided by 1 cohort, including 2,306 cases (Mozaffarian D [13]).
No association was found with total CHD, sudden death, or nonfatal MI.
Effect modification: No associations were found statified by age, BMI, or intakes of EPA/DHA, alpha-linolenic acid, and trans fat.
Subjects with prevalent disease: No data was found.

Conclusion: No associations were found. No evidence was found for an association between consumption of total dietary omega-6 fatty acids and coronary heart disease.

**Prospective studies of dietary omega 6 fatty acids and coronary heart disease:**
Author	Cohort name	Cases	End point	Relative Risk (RR)
Mozaffarian D (2005)	The Health Professionals Follow-up Study	2,306	Risk	HR = 0.96 (0.89-1.04).

Total omega 6 fatty acids and stroke.

Results: Data about any stroke end point was provided by 3 cohorts, including 966 cases.
No significant associations were found. RR's were available for only 2 out of 6 end points.
Effect modification: No data was found.
Subjects with prevalent disease: No data was found.

Conclusion: No associations were found. No evidence was found for an association between consumption of total dietary omega-6 fatty acids and stroke.

**Prospective studies of dietary omega 6 fatty acids and stroke:**
Author	Cohort name	Cases	End point	Relative Risk (RR)
25) Iso H (2003)	No cohort name defined	68 intraparenchymal hemorrhage, 41 subarachnoid hemorrhage, and 166 ischemic stroke	Risk	Intraparenchymal hemorrhage: RR = 1.14 (0.59-2.22; P = 0.93). Subarachnoid hemorrhage: No significant association. Ischemic stroke: No significant association.
13) He K	The Health Professionals Follow Up Study	455 ischemic stroke, and 125 hemorrhagic stroke	Risk	Ischemic stroke: No significant association. Hemorrhagic stroke: No significant association.
9) Seino F (1997)	The Shibata Study	141	Risk	RR = 1.54 (0.52-4.56; P = 0.71).
		Total number of cases: 996		Average RR = ?

Sudden death
(218? cases)

Nonfatal MI
(1,521? cases)

Total CHD
(2,306? cases)

HR = 0.82 (0.63-1.06) for each 5 g/d.

HR = 1.00 (0.91-1.11) for each 5 g/d.

HR = 0.96 (0.89-1.04) for each 5 g/d.

Also, no association was found for the highest vs lowest decile of consumption (data not shown).

Effect modification: Little evidence was found for effect modification by age, BMI, or intake of trans fatty acids (P = > 0.10 for each interaction. Data not shown).

Sudden death.
Stratified by EPA/DHA consumption:

Low EPA + DHA (< 250 mg/d)
(127 cases)

High EPA + DHA (≥ 250 mg/d)
(91 cases)

Low n-6: RR = 1 (Reference) for < 11.2 g/d.
High n-6: RR = 0.76 (0.52-1.11) for ≥ 11.2 g/d.

Low n-6: RR = 0.52 (0.34-0.79) for < 11.2 g/d.
High n-6: RR = 0.60 (0.39-0.93) for ≥ 11.2 g/d.

Nonfatal MI.
Stratified by EPA/DHA consumption:

Low EPA + DHA (< 250 mg/d)
(744 cases)

High EPA + DHA (≥ 250 mg/d)
(777 cases)

Low n-6: RR = 1 (Reference) for < 11.2 g/d.
High n-6: RR = 1.09 (0.93-1.28) for ≥ 11.2 g/d.

Low n-6: RR = 1.16 (0.99-1.36) for < 11.2 g/d.
High n-6: RR = 1.09 (0.91-1.29) for ≥ 11.2 g/d.

Total CHD.
Stratified by EPA/DHA consumption:

Low EPA + DHA (< 250 mg/d)
(1,125 cases)

High EPA + DHA (≥ 250 mg/d)
(1,181 cases)

Low n-6: RR = 1 (Reference) for < 11.2 g/d.
High n-6: RR = 0.97 (0.85-1.10) for ≥ 11.2 g/d.

Low n-6: RR = 1.05 (0.92-1.19) for < 11.2 g/d.
High n-6: RR = 1.02 (0.89-1.16) for ≥ 11.2 g/d.

Sudden death.
Stratified by ALA consumption:

Low ALA (< 1080 mg/d)
(102 cases)

High ALA (≥ 1080 mg/d)
(116 cases)

Low n-6: RR = 1 (Reference) for < 11.2 g/d.
High n-6: RR = 0.88 (0.56-1.36) for ≥ 11.2 g/d.

Low n-6: RR = 0.95 (0.64-1.43) for < 11.2 g/d.
High n-6: RR = 0.93 (0.64-1.35) for ≥ 11.2 g/d.

Nonfatal MI.
Stratified by ALA consumption:

Low ALA (< 1080 mg/d)
(775 cases)

High ALA (≥ 1080 mg/d)
(746 cases)

Low n-6: RR = 1 (Reference) for < 11.2 g/d.
High n-6: RR = 0.98 (0.84-1.15) for ≥ 11.2 g/d.

Low n-6: RR = 0.85 (0.72-0.99) for < 11.2 g/d.
High n-6: RR = 0.89 (0.77-1.02) for ≥ 11.2 g/d.

Total CHD.
Stratified by ALA consumption:

Low ALA (< 1080 mg/d)
( cases)

High ALA (≥ 1080 mg/d)
( cases)

Low n-6: RR = 1 (Reference) for < 11.2 g/d.
High n-6: RR = 0.93 (0.82-1.07) for ≥ 11.2 g/d.

Low n-6: RR = 0.88 (0.78-0.99) for < 11.2 g/d.
High n-6: RR = 0.89 (0.79-0.99) for ≥ 11.2 g/d.

Ischaemic stroke
(embolism or thrombosis)
(455? cases)

Haemorrhagic stroke
(subarachnoid and intracerebral)
(125? cases)

No significant association was found (no data shown).

Cardiovascular disease & Diet. A systematic review.

Literature review.

Relating various aspects of our
diet to heart disease and stroke.

Consumption of total dietary omega 6 fatty acids and cardiovascular disease.

Total omega 6 fatty acids and total cardiovascular disease (CVD).

Total omega 6 fatty acids and coronary heart disease (CHD).

Total omega 6 fatty acids and stroke.

Cardiovascular disease & Diet. A systematic review.

Literature review.

Relating various aspects of ourdiet to heart disease and stroke.

Consumption of total dietary omega 6 fatty acids and cardiovascular disease.

Total omega 6 fatty acids and total cardiovascular disease (CVD).

Total omega 6 fatty acids and coronary heart disease (CHD).

Total omega 6 fatty acids and stroke.

Relating various aspects of our
diet to heart disease and stroke.