Coronary heart disease: Data was provided by 4 cohorts. A significant protective effect against MI mortality was found in one Asian cohort (Yuan JM [19]).
Stroke: Data was provided by 2 cohorts. No associations were found.
Conclusion: Few associations were found. Inconclusive evidence was found for an association between shellfish consumption and cardiovascular disease.
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 39) Matheson EM (2009) | The Atherosclerosis Risk in Communities (ARIC) | 13,335 subjects aged 45-64, and without a history of CHD or stroke. (USA) | 1987-89 to 2001 | 1,382 | Coronary heart disease incidence (MI or CHD death) | Shellfish (shrimp, lobster, or scallops as a main dish) |
HR = 0.98 (0.82-1.18) for the highest vs lowest tertile of consumption. Amount specific data (Frequency of consumption): Almost never: HR = 1. 1-3 times/mo: HR = 0.91 (0.80-1.03). ≥ 1 time/wk: HR = 0.98 (0.82-1.18). | Age, sex, race, smoking status, exercise status, family history of heart disease, HDL cholesterol level, LDL cholesterol level, hypertension, and diabetes. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 19) Yuan JM (2001) | The Shanghai Cohort Study | 18,244 men aged 45-64 from Shanghai (China), and without a history of cancer. | 12 (1986-89 to 1998) | See variables | Ischemic heart disease death | Shellfish (e.g., shrimp and crab) |
Age, total energy intake, level of education, BMI, current smoking, cigarettes smoked, alcohol, history of diabetes, and history of hypertension. |
Separate inclusion of intake levels of red meats; poultry; vegetables; fruit; soybeans and soy products; legumes; carbohydrate; protein; total fat; saturated, monounsaturated, and polyunsaturated fats other than n-3 fatty acids; and cholesterol did not materially alter the association with fatal MI. 15) Albert CM (1998) | The Physician's Health Study | 20,551 men aged 40-84, and without a history of MI, stroke, transient ischemic attack, or cancer. | (USA) 11 | (1983-1995) 133? | Sudden cardiac death | Shellfish (shrimp, lobster, or scallops as a main dish) | RR = 0.69 (0.35-1.34) for consumption ≥ 1 serving/wk vs < 1 serving/month. | Age, aspirin and beta carotene treatment assignment, evidence of CVD, BMI, smoking status, history of diabetes, history of hypertension, history of hypercholesterolemia, alcohol, vigorous exercise, vitamine E, vitamin C, and multivitamin use. |
15) Morris MC (1995) | The Physician's Health Study | 21,185 men aged 40-84, and without a history of MI, stroke, transient ischemic attacks, cancer, liver/renal disease, peptic ulcer, gout, current use of aspirin, other platelet-active drugs, or NSAID's. | (USA) 4 | (1983-1988) 280 | Fatal and nonfatal myocardial infarction (excluding silent infarctions) | Shrimp, lobster, and scallops as a main dish |
RR = 1.1 (0.7-1.8; P = 0.86) for the highest vs lowest quartile of consumption. | Amount specific data (meals/week): Rarely/never: RR = 1. 1-3 times/month: RR = 1.2 (0.9-1.8). 1 time/week: RR = 1.0 (0.7-1.6). ≥ 2 times/week: RR = 1.1 (0.7-1.8). Age, aspirin and beta-carotene assignment, smoking, alcohol consumption, obesity, diabetes mellitus, vigorous exercise, parental history of MI, history of hypertension, history of hypercholesterolemia, vitamin supplement use, and saturated fat intake. |
14) Hu FB (2003) | The Nurses' Health Study | 5,103 women with physician-diagnosed type 2 diabetes mellitus. | 1984-96 | ? | CHD incidence | Shrimp, lobster or scallops as main dish | An inverse association: RR = 0.43 (0.06-3.14; No P-value) for consumption ≥ 2 times/wk vs < 1 time/month. | Frequency of consumption was defined in portion units of 3-5 oz. Age, time intervals, smoking status, BMI, alcohol intake, parental history of MI, menopausal status and postmenopausal hormone use, moderate to vigorous activities, usual aspirin use, multivitamin supplement use, vitamin E supplement use, history of hypertension, hypercholesterolemia, duration of diabetes, and hypoglycemic medication. |
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