Consumption of dietary vegetable fat and cardiovascular disease.
Vegetable fat and total cardiovascular disease (CVD).
Data about the relation between vegetable fat consumption and total cardiovascular disease was provided by one cohort, including women with type 2 diabetes only (Tanasescu M [13]). No significant association was found: RR = 0.75 (0.53-1.06; P = 0.12).
Vegetable fat and coronary heart disease (CHD).
Results: Data was provided by 4 cohorts, including 2,192 cases.
A significant protective effect was found in one cohort of large size (Halton TL [13]). No other associations were found. The average RR could not be calculated
because the number of cases + the RR was available from one cohort only.
Effect modification: No data was found.
Subjects with prevalent disease: No data was found.
Conclusion: A significant protective effec was found in 1 out of 4 cohorts. Inconclusive evidence was found for an association between vegetable fat
consumption and coronary heart disease.
| Author | Cohort name | Cases | End point | Relative Risk (RR) |
|---|---|---|---|---|
| 13) Halton TL (2006) | The Nurses' Health Study | 1,994 | Risk | RR = 0.75 (0.57-0.98). |
| 9) Tanaka H (1987) | The Shibata Study | Not defined | Risk | RR = 1.51 |
| 8) Kushi LH (1985) | The Ireland-Boston Diet-Heart Study | 110 | Mortality | No significant association (P = 0.83). |
| 1) Oglesby P (1963) | The Western Electric Study | 88 | Risk | No significant association. |
| Total number of cases: 2,192 | Average RR = ? |
Vegetable fat and stroke.
Results: Data was provided by 2 cohorts, including 640 cases.
No significant associations were found. The average RR = 1.08.
Effect modification: No data was found.
Subjects with prevalent disease: No data was found.
Conclusion: No associations were found. No evidence was found for an association between vegetable fat consumption and stroke.
| Author | Cohort name | Cases | End point | Relative Risk (RR) |
|---|---|---|---|---|
| 30) Sauvaget C (2004) | The Adult Health Study | 60 | Ischemic stroke mortality | RH = 1.43 (0.69-2.95; P = 0.32). |
| 13) He K (2003) | The Health Professionals Follow Up Study | 455 ischemic stroke, and 125 hemorrhagic stroke | Risk | Ischemic stroke: RR = 1.09 (0.78-1.51; P = 0.79). Hemorrhagic stroke: RR = 0.86 (0.45-1.64; P = 0.80). |
| Total number of cases: 640 | Average RR = 1.08 |
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments |
| 13) Tanasescu M (2004) | The Nurses' Health Study | 5,672 women with type 2 diabetes, but without CVD or cancer. | 1980 to 1994-98 | 619? | CVD events (nonfatal myocardial infarction, fatal coronary heart disease, and stroke) | Vegetable fat (not defined) |
RR = 0.75 (0.53-1.06; P = 0.12) for the highest vs lowest quintile of consumption. Amount specific data (% of energy): 4.5: RR = 1. 7.9: RR = 1.09 (0.85-1.39). 10.4: RR = 1.01 (0.77-1.33). 12.8: RR = 1.00 (0.75-1.35). 16.7: RR = 0.75 (0.53-1.06). | Age, smoking, postmenopausal hormone use, parental history of MI before age 60, alcohol intake, moderate vigorous activities, BMI, total caloric intake, protein intake, fiber intake, multivitamin use, vitamin E supplement use, medication use, animal fat, cholesterol, and trans fat. |
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 13) Halton TL (2006) | The Nurses' Health Study | 82,802 women aged 34-59, and without diabetes, cancer, or cardiovascular disease. | 20 (1980-2000) | 1,994? | Coronary heart disease incidence (nonfatal myocardial infarctions or fatal coronary events) | Vegetable fat (not defined) |
RR = 0.75 (0.57-0.98; P = 0.006) for the highest vs lowest decile of consumption. Amount specific data (Deciles not defined): D1: RR = 1. D2: RR = 0.87 (0.70-1.09). D3: RR = 1.10 (0.89-1.37). D4: RR = 1.01 (0.81-1.27). D5: RR = 0.94 (0.74-1.18). D6: RR = 0.99 (0.78-1.25). D7: RR = 0.87 (0.68-1.11). D8: RR = 0.82 (0.64-1.06). D9: RR = 0.82 (0.63-1.06). D10: RR = 0.75 (0.57-0.98). | Age, BMI, smoking status, postmenopausal hormone use, hours of physical activity, alcohol intake, aspirine use, use of multivitamins, use of vitamin E supplement use, history of hypertension, history of hypercholesterolemia, parental history of myocardial infarction, protein, total calories, animal fat, and trans fat. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 13) Hu FB (1997) | The Nurses' Health Study | 80,082 women aged 34-59 and without CVD, diabetes, hypercholesterolemia, or cancer. | 14 (1980-1994) | 939? | Coronary heart disease incidence (nonfatal myocardial infarction or fatal coronary disease) | Vegetable fat (not defined) |
RR = 0.67 (0.51-0.88; P = 0.009) for the highest vs lowest quintile of consumption. Amount specific data (% of energy): 5.4: RR = 1. 8.8: RR = 0.82 (0.67-1.01). 11.2: RR = 0.96 (0.78-1.20). 13.5: RR = 0.82 (0.64-1.04). 17.2: RR = 0.67 (0.51-0.88). | Age, time period, BMI, cigarette smoking, menopausal status, parental history of MI before age 65, multivitamin use, vitamin E supplement use, alcohol consumption, history of hypertension, aspirin use, vigorous exercise, % energy from protein, dietary cholesterol, animal fat, and trans unsaturated fats. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 9) Tanaka H (1987) | The Shibata Study | 963 men + 1,338 women aged ≥ 40, and without ischemic heart disease. (Japan) | 7.5 (1977-1984) | Not defined. | Ischemic heart disease risk (MI + angina pectoris + sudden death) | Vegetable fat (not defined) |
Sex and age. |
8) Kushi LH (1985) | The Ireland-Boston Diet-Heart Study | 1,001 middle-aged men of Irish descent. | 20 | (1959-65 to 1982) 110? | CHD mortality (death from coronary or ischemic disease) | Vegetable fat (not defined) | Cases consumed the same % of calories from vegetable fat (6.7) as noncases (6.8; P = 0.83). | Age and cohort. |
1) Paul O/ | Oglesby P (1963) The Western Electric Study | 1,885 American men of Polish and Bohemian ancestry aged 40-55 without a history of MI or angina pectoris. | 4.5 | (1957-?) 88? | CHD risk (angina pectoris, MI, or CHD death. excluding sudden death) | Vegetable fat (not defined) | No significant difference was apparent between cases (32 g/day), and controls (34 g/day; no data shown). | Unadjusted. |
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