Data about avocados was provided by 3 cohorts. No associations were found with colon, or rectal (6), or total colorectal (23) cancer risk.
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| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments |
| 23)Lin J. (2005) | The Women's Health Study. | 36,976 women aged > or = 45 years. (USA) | 10 | 222? | Colorectal cancer risk | Avocados | Intakes of individual fruit items were found not appreciably to be associated with colorectal cancer risk (data not shown). | age, randomized treatment assignment, BMI, family history of colorectal cancer, history of colon polyps, physical activity, smoking status, baseline aspirin use, red meat intake, alcohol consumption, total energy intake, menopausal status, baseline post-menopausal HT use, folate intake and multivitamin use. Glycemic load in the multivariate model did not change the overall results. |
| 6) Michels KB. (2000) | The Nurses' Health Study & The Health Professionals' Follow-up Study. | 88,764 women aged 34-59 and 47,325 men aged 40-75. (USA) | Women: 16 (1980-1996). Men: 10 (1986-1996) | 1,181? (937 colon cancer [368 men, 569 women], 244 rectal cancer [89 men, 155 women]) | Colorectal cancer risk | Avocados | Intake of individual vegetables that constitute the composite items was not appreciably associated with colon or rectal cancer risk in women or men (No data shown). Note that avocado consumption was only measured in 1 (out of 4) of the female FFQs (1986), and in 1 (out of 2) of the male FFQs (1986). | age, family history of colorectal cancer, sigmoidoscopy, height, body mass index, pack-years of smoking, alcohol intake, physical activity, (women: menopausal status, postmenopausal hormone use,) aspirin use, vitamin supplement intake (ever use of multivitamins or vitamins A, C, or E), total caloric intake, and red meat consumption. |
| 6) Giovannucci E. (1994) | The Health Professionals Follow-up Study. | 47,949 men aged 40-75. (USA) | 1986-1992 | 205? | Colon cancer risk | avocados | Of all fruits items examined individually, none were statistically significantly related to the risk of colon cancer (no data shown). | Age, energy. |