Legumes (pulses) and esophageal cancer.

Esophageal cancer risk: Data about the relation with esophageal cancer risk was provided by one cohort (7). No association was found.

Esophageal cancer mortality: Data about the relation with esophageal cancer mortality was provided by one cohort (6). No association was found.

Conclusion: No associations were found. No evidence was found for an association between legumes and esophageal cancer.

Author

Cohort name

Subjects

Years of follow-up

Cases

End point

Consumption of

Relative Risk (RR)

Adjustments

7) Freedman ND (2007)

The NIH-AARP Diet and Health Study

490,802 (292,898 men and 197,904 women).
(USA)

5
(1995-96 to 2000)

ESCC: 103.

EAC: 213.

Esophageal cancer incidence

Leguminosae (dried beans, string beans and peas)


ESCC:	EAC:
HR = 0.80 (0.50-1.29) for the highest vs lowest tertile of consumption. Amount specific data (servings/1,000 calories): 0.12: HR = 1. 0.28: HR = 0.66 (0.41-1.06). 0.59: HR = 0.80 (0.50-1.29).	HR = 0.92 (0.65-1.29) for the highest vs lowest tertile of consumption. Amount specific data (servings/1,000 calories): 0.12: HR = 1. 0.28: HR = 0.98 (0.71-1.34). 0.59: HR = 0.92 (0.65-1.29).

Sex, age at entry into cohort, BMI, education, alcohol intake, cigarette-smoke-dose, vigorous physical activity, usual activity throughout the day and total energy.

6) Iso H (2007)

The JACC Study.

41,816 men, and 57,985 women.
(Japan)

Not defined.

134 men, and
24 women.

Esophageal cancer mortality

Boiled beans (not defined)


Men:	Women:
HR = 0.81 (0.48-1.35) for the highest vs lowest tertile of consumption. Amount specific data: < 1/w: HR = 1. 1-2/w: HR = 0.59 (0.35-0.97; P = < 0.05). ≥ 3/w: HR = 0.81 (0.48-1.35).	HR = 0.47 (0.13-1.68) for the highest vs lowest tertile of consumption. Amount specific data: < 1/w: HR = 1. 1-2/w: HR = 1.09 (0.45-2.63). ≥ 3/w: HR = 0.47 (0.13-1.68).

Age and study area.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our diet
to esophageal cancer risk & mortality.

Legumes (pulses) and esophageal cancer.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our dietto esophageal cancer risk & mortality.

Legumes (pulses) and esophageal cancer.

Relating various aspects of our diet
to esophageal cancer risk & mortality.