Potatoes and ovarian cancer.

Ovarian cancer risk: Data about the relation with ovarian cancer risk was provided by a pooled analysis of 11 cohorts (9). No association was found.

Ovarian cancer mortality: Data about the relation with ovarian cancer mortality was provided by 2 cohorts. An increased mortality risk of fried potatoes was found in one cohort (1), but no association with potatoes was found in the other cohort (10).

Conclusion: Effects were restricted to findings from one cohort. No evidence was found for an association between potatoes and ovarian cancer.

Author	Cohort name	Subjects	Years of follow-up	Cases	End point	Consumption of	Relative Risk (RR)	Adjustments
10) Sakauchi F (2007)	The JACC Study.	64,327 women aged 40-79. (Japan)	13.3 (1988-90 to 2003)	71	Ovarian cancer mortality	Potatoes	HR = 1.54 (0.66-3.61; P = 0.33) for the highest vs lowest tertile of consumption. Amount specific data (intake frequency): ≤ 2 times/week: HR = 1. 3-4 times/week: HR = 1.15 (0.52-2.56). Almost every day: HR = 1.54 (0.66-3.61).	Age, menopausal status, number of pregnancies, history of sex hormone use, BMI, physical activity, and education.
9) Koushik A (2005)	Pooled analysis of 11 cohort studies.	542,039 women.	7-22	2,068	Invasive epithelial ovarian cancer risk	Potatoes (not including French fried potatoes or chips)	INCLUSION CRITERIA: At least 50 incident invasive epithelial ovarian cancer cases. An assessment of usual diet. A validation study of the diet assessment method or a closely related instrument. INCLUDED STUDIES (Follow-up years/No. of ovarian cancer casses): The Breast Cancer Detection Demonstration Project (1987-1999/142). Hannan LM. Physical activity and risk of ovarian cancer: a prospective cohort study in the United States. Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):765-70. Full text The Canadian National Breast Screening Study (1980-2000/223). Terry PD. Cigarette smoking and the risk of invasive epithelial ovarian cancer in a prospective cohort study. Eur J Cancer. 2003 May;39(8):1157-64. Abstract The Cancer Prevention Study II Nutrition Cohort (1992-2001/278). Calle EE. The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. Cancer. 2002 Jan 15;94(2):500-11. Abstract The Iowa Women's Health Study (1986-2001/208). Kushi LH. Prospective study of diet and ovarian cancer. Am J Epidemiol. 1999 Jan 1;149(1):21-31 Full text The Netherlands Cohort Study (1986-1995/208). Mommers M. Consumption of vegetables and fruits and risk of ovarian carcinoma. Cancer. 2005 Oct 1;104(7):1512-9. Full text The New York State Cohort (1980-1987/77). Bandera EV. Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control. 1997 Nov;8(6):828-40. Abstract The New York University Women's Health Study (1985-1998/65). Kato I. Prospective study of diet and female colorectal cancer: the New York University Women's Health Study. Nutr Cancer. 1997;28(3):276-81. Abstract The Nurses' Health Study A + B (A = 1980-1986/120. B = 1986-2002/315). Fairfield KM. Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis. Cancer. 2001 Nov 1;92(9):2318-26. Full text The Nurses' Health Study II (1991-2000/52). Cho E. Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst. 2003 Jul 16;95(14):1079-85. Full text The Swedish Mammography Cohort (1987-2004/285). Larsson SC. Fruit and vegetable consumption in relation to ovarian cancer incidence: the Swedish Mammography Cohort. Br J Cancer. 2004 Jun 1;90(11):2167-70. Full text The Women's Health Study (1993-2004/104). Higginbotham S. Dietary glycemic load and breast cancer risk in the Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):65-70. Full text RELATIVE RISK: RR = 0.97 (0.81-1.15) for a daily increment of 1 serving (= 1 potato, or 1 cup potatoes, or 202 g). P for between-studies heterogeneity = 0.66.	Parity, oral contraceptive use, menopausal status and postmenopausal hormone use, age at menarche, BMI, physical activity, smoking status, and total energy intake. Age in years and year of questionnaire return were included as stratification variables.
1) Snowdon DA (1985)	The Adventist Health Study	16,190 white California Seventh-Day Adventists women.	1960-1980	50?	Ovarian cancer death	Fried potatoes	A positive association (no data shown). Other findings suggested that the association was not due to the confounding effect of marital status, age at menarche, age at first birth, number of pregnancies, or age at natural or surgical menopause.	Age.

Author

Cohort name

Subjects

Years of follow-up

Cases

End point

Consumption of

Relative Risk (RR)

Adjustments

10) Sakauchi F (2007)

The JACC Study.

64,327 women aged 40-79.
(Japan)

13.3
(1988-90 to 2003)

Ovarian cancer mortality

Potatoes

HR = 1.54 (0.66-3.61; P = 0.33) for the highest vs lowest tertile of consumption.

Amount specific data (intake frequency):
≤ 2 times/week: HR = 1.
3-4 times/week: HR = 1.15 (0.52-2.56).
Almost every day: HR = 1.54 (0.66-3.61).

Age, menopausal status, number of pregnancies, history of sex hormone use, BMI, physical activity, and education.

9) Koushik A (2005)

Pooled analysis of 11 cohort studies.

542,039 women.

7-22

2,068

Invasive epithelial ovarian cancer risk

Potatoes (not including French fried potatoes or chips)

INCLUSION CRITERIA:

At least 50 incident invasive epithelial ovarian cancer cases.
An assessment of usual diet.
A validation study of the diet assessment method or a closely related instrument.

INCLUDED STUDIES (Follow-up years/No. of ovarian cancer casses):

The Breast Cancer Detection Demonstration Project (1987-1999/142).
Hannan LM. Physical activity and risk of ovarian cancer: a prospective cohort study in the United States. Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):765-70. Full text
The Canadian National Breast Screening Study (1980-2000/223).
Terry PD. Cigarette smoking and the risk of invasive epithelial ovarian cancer in a prospective cohort study. Eur J Cancer. 2003 May;39(8):1157-64. Abstract
The Cancer Prevention Study II Nutrition Cohort (1992-2001/278).
Calle EE. The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. Cancer. 2002 Jan 15;94(2):500-11. Abstract
The Iowa Women's Health Study (1986-2001/208).
Kushi LH. Prospective study of diet and ovarian cancer. Am J Epidemiol. 1999 Jan 1;149(1):21-31 Full text
The Netherlands Cohort Study (1986-1995/208).
Mommers M. Consumption of vegetables and fruits and risk of ovarian carcinoma. Cancer. 2005 Oct 1;104(7):1512-9. Full text
The New York State Cohort (1980-1987/77).
Bandera EV. Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control. 1997 Nov;8(6):828-40. Abstract
The New York University Women's Health Study (1985-1998/65).
Kato I. Prospective study of diet and female colorectal cancer: the New York University Women's Health Study. Nutr Cancer. 1997;28(3):276-81. Abstract
The Nurses' Health Study A + B (A = 1980-1986/120. B = 1986-2002/315).
Fairfield KM. Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis. Cancer. 2001 Nov 1;92(9):2318-26. Full text
The Nurses' Health Study II (1991-2000/52).
Cho E. Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst. 2003 Jul 16;95(14):1079-85. Full text
The Swedish Mammography Cohort (1987-2004/285).
Larsson SC. Fruit and vegetable consumption in relation to ovarian cancer incidence: the Swedish Mammography Cohort. Br J Cancer. 2004 Jun 1;90(11):2167-70. Full text
The Women's Health Study (1993-2004/104).
Higginbotham S. Dietary glycemic load and breast cancer risk in the Women's Health Study. Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):65-70. Full text

RELATIVE RISK:

RR = 0.97 (0.81-1.15) for a daily increment of 1 serving (= 1 potato, or 1 cup potatoes, or 202 g).

P for between-studies heterogeneity = 0.66.

Parity, oral contraceptive use, menopausal status and postmenopausal hormone use, age at menarche, BMI, physical activity, smoking status, and total energy intake. Age in years and year of questionnaire return were included as stratification variables.

1) Snowdon DA (1985)

The Adventist Health Study

16,190 white California Seventh-Day Adventists women.

1960-1980

50?

Ovarian cancer death

Fried potatoes

A positive association (no data shown).

Other findings suggested that the association was not due to the confounding effect of marital status, age at menarche, age at first birth, number of pregnancies, or age at natural or surgical menopause.

Age.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our diet
to ovarian cancer risk & mortality.

Potatoes and ovarian cancer.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our dietto ovarian cancer risk & mortality.

Potatoes and ovarian cancer.

Relating various aspects of our diet
to ovarian cancer risk & mortality.