Ovarian cancer risk: Data about the relation with ovarian cancer risk was provided by 2 cohorts. No associations were found with tofu (11, 13).
Ovarian cancer mortality: Data about the relation with ovarian cancer mortality was provided by 2 cohorts. No associations were found with miso soup (2),
or tofu (10).
Conclusion: No associations were found. No evidence was found for an association between soy and ovarian cancer.
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments |
| 13) Wang L (2009) | The Women's Health Study | 38,408 female health professionals aged ≥ 45. (USA) | 11.5 (1992-95 to 2007) | 141? | Ovarian cancer incidence | Tofu | Risk did not materially change with intake (data not shown). | Age, race, total energy, randomized treatment assignment, smoking, alcohol use, physical activity, postmenopausal status, hormone replacement therapy use, multivitamin use, family history of colorectal cancer, ovary cancer, or breast cancer, and intake of fruit and vegetables, fiber, folate, and saturated fat. |
| 11) Chang ET (2007) | The California Teachers Study Cohort | 97,275 women aged ≤ 84 without a history of bilateral oophorectomy. | 1995-96 to 2003 | 280 | Ovarian cancer risk | Tofu/bean curd |
RR = 0.76 (0.46-1.24; P = 0.22) for the highest vs lowest tertile of consumption. Amount specific data (g): 0: RR = 1. > 0-< 10: RR = 0.87 (0.55-1.39). ≥ 10: RR = 0.76 (0.46-1.24). There were no substantial differences when the analysis was restricted to peri-/postmenopausal women, nor when the cases were limited to invasive or serous ovarian cancer only (data not shown). | Race, total energy intake, parity, oral contraceptive use, strenuous exercise, wine consumption, and menopausal status/hormone therapy use; stratified by age at baseline. |
| 10) Sakauchi F (2007) | The JACC Study. | 64,327 women aged 40-79. (Japan) | 13.3 (1988-90 to 2003) | 64 | Ovarian cancer mortality | Soybean curd (tofu) |
HR = 0.61 (0.26-1.45; P = 0.27) for the highest vs lowest tertile of consumption. Amount specific data (intake frequency): ≤ 2 times/week: HR = 1. 3-4 times/week: HR = 0.90 (0.42-1.92). Almost every day: HR = 0.61 (0.26-1.45). | Age, menopausal status, number of pregnancies, history of sex hormone use, BMI, physical activity, and education. |
| 2) Hirayama T. (1990) | No cohort name. | 265,118 adults (122,261 men, 142,857 women) aged ≥ 40 from 6 prefectures in Japan. | 17 (1966-1982) | 106? | Ovarian cancer mortality | Soybean paste soup | RR = 1.02 (90% CI = 0.72-1.45; No P-value) for consumption ≥ 4 vs ≤ 3 times/wk. | Age. |