| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments |
| 18) Vrieling A (2009) | The EPIC Study | 478,400 subjects from 10 European countries. | 8.9 (1991-2000 to 2002-2007) | 555 | Invasive exocrine pancreatic cancer incidence | Other fruit and fruit not-specified (e.g. kiwis, bananas). |
HR = 0.97 (0.73-1.28; P = 0.76) for the highest vs lowest quartile of consumption.
Amount specific data (g/day):
< 17: HR = 1.
17-45: HR = 1.03 (0.81-1.30).
45-95: HR = 1.00 (0.78-1.29).
> 95: HR = 0.97 (0.73-1.28). | Stratified by age at entry, sex and center. Adjusted for energy from fat, energy from non-fat, weight, height, history of diabetes, and smoking status.
Waist-to-hip ratio, alcohol, red meat and processed meat intake, and education did not markedly change the risk estimates. |
| 18) Vrieling A (2009) | The EPIC Study | 478,400 subjects from 10 European countries. | 8.9 (1991-2000 to 2002-2007) | 555 | Invasive exocrine pancreatic cancer incidence | Hard fruit (e.g. apples, pears) |
HR = 1.04 (0.80-1.35; P = 0.49) for the highest vs lowest quartile of consumption.
Amount specific data (g/day):
< 16: HR = 1.
16-48: HR = 0.88 (0.68-1.13).
48-106: HR = 1.02 (0.80-1.32).
> 106: HR = 1.04 (0.80-1.35). | Stratified by age at entry, sex and center. Adjusted for energy from fat, energy from non-fat, weight, height, history of diabetes, and smoking status.
Waist-to-hip ratio, alcohol, red meat and processed meat intake, and education did not markedly change the risk estimates. |
| 18) Vrieling A (2009) | The EPIC Study | 478,400 subjects from 9 European countries (excluding Norway and Umea center from Sweden). | 8.9 (1991-2000 to 2002-2007) | 509 | Invasive exocrine pancreatic cancer incidence | Stone fruit (e.g. peaches, cherries) |
HR = 1.03 (0.76-1.39; P = 0.76) for the highest vs lowest quartile of consumption.
Amount specific data (g/day):
< 2: HR = 1.
2-13: HR = 0.97 (0.75-1.25).
13-41: HR = 0.93 (0.71-1.22).
> 41: HR = 1.03 (0.76-1.39). | Stratified by age at entry, sex and center. Adjusted for energy from fat, energy from non-fat, weight, height, history of diabetes, and smoking status.
Waist-to-hip ratio, alcohol, red meat and processed meat intake, and education did not markedly change the risk estimates. |
| 18) Vrieling A (2009) | The EPIC Study | 478,400 subjects from 10 European countries. | 8.9 (1991-2000 to 2002-2007) | 555 | Invasive exocrine pancreatic cancer incidence | Fruiting vegetables (not defined) |
HR = 0.96 (0.72-1.28; P = 0.68) for the highest vs lowest quartile of consumption.
Amount specific data (g/day):
< 25: HR = 1.
25-49: HR = 1.03 (0.81-1.30).
49-88: HR = 0.90 (0.70-1.17).
> 88: HR = 0.96 (0.72-1.28). | Stratified by age at entry, sex and center. Adjusted for energy from fat, energy from non-fat, weight, height, history of diabetes, and smoking status.
Waist-to-hip ratio, alcohol, red meat and processed meat intake, and education did not markedly change the risk estimates. |
| 15) Iso H (2007) | The JACC Study. | 41,395 men, and 56,195 women. (Japan) | Not defined. | 185 men, and 187 women. | Pancreas cancer mortality | Fruits other than citrus fruits (not defined) |
| Men: | Women: |
HR = 0.67 (0.44-1.02; P = < 0.10) for the highest vs lowest tertile of consumption.
Amount specific data:
< 3/w: HR = 1.
3-4/w: HR = 0.96 (0.64-1.45).
≥ 5/w: HR = 0.67 (0.44-1.02).
|
HR = 1.11 (0.76-1.62) for the highest vs lowest tertile of consumption.
Amount specific data:
< 3/w: HR = 1.
3-4/w: HR = 1.29 (0.86-1.94).
≥ 5/w: HR = 1.11 (0.76-1.62).
|
Age and study area. |
| 15) Lin Y (2006) | The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) | 46,465 men and 64,327 women aged 40-79. | 10 (1988-90 to 1999) | See variables | Pancreatic cancer death | Fruits other than citrus (not defined) |
Stratified by gender:
Men (100 cases) | women (118 cases) |
HR = 0.71 (0.35-1.45; P = 0.29) for the highest vs lowest tertile of consumption.
Amount specific data (Frequency of intake):
0-2/mo: HR = 1.
1-4/wk: HR = 1.43 (0.82-2.49).
Almost every day: HR = 0.71 (0.35-1.45).
|
HR = 0.65 (0.36-1.16; P = 0.09) for the highest vs lowest tertile of consumption.
Amount specific data (Frequency of intake):
0-2/mo: HR = 1.
1-4/wk: HR = 0.86 (0.49-1.50).
Almost every day: HR = 0.65 (0.36-1.16).
|
Stratified by smoking status:
Smokers (60 cases) | Nonsmokers (109 cases) |
HR = 0.95 (0.40-2.28; P = 0.86) for the highest vs lowest tertile of consumption.
Amount specific data (Frequency of intake):
0-2/mo: HR = 1.
1-4/wk: HR = 1.71 (0.85-3.44).
Almost every day: HR = 0.95 (0.40-2.28).
|
HR = 0.54 (0.29-0.98; P = 0.02) for the highest vs lowest tertile of consumption.
Amount specific data (Frequency of intake):
0-2/mo: HR = 1.
1-4/wk: HR = 0.87 (0.50-1.52).
Almost every day: HR = 0.54 (0.29-0.98).
|
Age, area, and pack-years of smoking.
Additional adjustment for potential confounders, such as history of diabetes, body mass index, alcohol consumption, and coffee and green tea consumption, did not alter the risk estimates materially. |
| 12) Michaud DS (2005) | The Health Professionals Follow-Up Study & The Nurses' Health Study | 47,493 men and 77,179 women. (USA) | Women: 1984-2000.
Men: 1986-2000. | 366? (185 men, and 181 women) | Pancreatic cancer incidence | Vegetables other than yellow, cruciferous, or leafy-green vegetables (not defined) | No substantial increase in risk was found (no data shown). | Age, pack-years of smoking, BMI, physical activity, history of diabetes mellitus, caloric intake, height, and multivitamin use. |
| 11) Khan MM. (2004) | No cohort name. | 1,524 men and 1,634 women aged ≥ 40 living in Hokkaido, Japan. | 1984-2002 | 12 men, 13 women? | Pancreatic cancer mortality | White pale vegetables (not defined) |
| Raw | Cooked |
Men: A nonsignificantly decreased risk: RR = 0.4 (0.1-1.2; No P-value). Women: RR = 1.3 (0.3-4.7; No P-value). | Men: Not estimated due to 0 case in either of the 2 groups. Women: RR = 1.1 (0.1-9.1; No P-value). |
RRs are for consumption ≥ several times/wk vs ≤ several times/month.Men: age and smoking. Women: age, health status, health education, health screening + smoking. |
| 1) Mills PK (1988) | The Adventist Health Study | 34,198 non-Hispanic white California Seventh-day Adventists aged ≥ 25. | 1976-82 | 40? | Pancreas cancer death | Other fresh fruit (not defined) | No association (no data shown). | Age and sex. |
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