Lettuce and prostate cancer.

Total prostate cancer risk: Data about the relation between lettuce and prostate cancer risk was provided by 2 cohorts.
In one cohort, a significantly increased risk was found of light green - but not dark green - lettuce (17). No association was found in the other cohort (10).
Advanced prostate cancer risk: Data about the relation with advanced stage prostate cancer risk was provided by one cohort (17). No association was found between light green lettuce and non-localized/high grade prostate cancer risk.
Prostate cancer mortality: No data was found.

Conclusion: Inconsistent findings were done. No evidence was found for an association between lettuce and prostate cancer.

| More information: back to literature review.|

Author

Cohort name

Subjects

Years of follow-up

Cases

End point

Consumption of

Relative Risk (RR)

Adjustments

17) Stram DO. (2006)

The multiethnic cohort study.

82,486 African-American, Japanese-American, Native-Hawaiian, Latino and White males aged 45-75.
(USA)

1993-96 to 2001

3,922?
(1,345 nonlocalized and high grade disease)

prostate cancer risk

Lettuce

**Prostate cancer risk:**
Dark green lettuce	Light green lettuce
RR = 1.02 (0.92-1.13; P = 0.874) for the highest vs lowest quintile of consumption. Amount specific data (g/1000 kcal): ≤ 0: RR = 1. > 0-≤ 1.2: RR = 1.02 (0.92-1.12). > 1.2-≤ 3.1: RR = 1.08 (0.98-1.19). > 3.1-≤ 8.9: RR = 1.07 (0.97-1.18). > 8.9: RR = 1.02 (0.92-1.13). Risk increased for latino men, but no associations were found for white, African-American, native Hawaiian, Japanese, and Latino men. (P for heterogeneity by ethnic group = 0.032).	RR = 1.14 (1.03-1.27; P = 0.006) for the highest vs lowest quintile of consumption. Amount specific data (g/1000 kcal): ≤ 1.2: RR = 1. > 1.2-≤ 3.2: RR = 1.02 (0.92-1.14). > 3.2-≤ 7.1: RR = 1.07 (0.96-1.18). > 7.1-≤ 14.4: RR = 1.12 (1.01-1.24). > 14.4: RR = 1.14 (1.03-1.27). (P for heterogeneity by ethnic group = 0.622).

Light green lettuce & non-localized or high grade prostate cancer risk:
RR = 1.00 (0.83-1.19; P = 1.000) for the highest vs lowest quintile of consumption.

Amount specific data (g/1000 kcal):
≤ 1.2: RR = 1.
> 1.2-≤ 3.2: RR = 0.99 (0.83-1.19).
> 3.2-≤ 7.1: RR = 1.14 (0.98-1.34).
> 7.1-≤ 14.4: RR = 1.10 (0.93-1.31).
> 14.4: RR = 1.00 (0.83-1.19).

age, BMI, education and family history of prostate cancer

10) Schuurman AG (1998)

The Netherlands Cohort Study.

58,279 men aged 55-69

6.3
((1986-1992)

606?

prostate cancer risk

Lettuce

No association: RR = 1.06 (0.71-1.59) per 25 g/day increment.

age, family history of prostate cancer, socioeconomic status and total fruit.
Additionaly adjusted for total vegetables.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our diet
to prostate cancer risk & mortality.

Lettuce and prostate cancer.

Cancer & Diet. A systematic review.

Literature review.

Relating various aspects of our dietto prostate cancer risk & mortality.

Lettuce and prostate cancer.

Relating various aspects of our diet
to prostate cancer risk & mortality.