Prostate cancer risk: Data about the relation with prostate cancer risk was provided by 3 cohorts. No association was found with orange (23), or
orange/grapefruit juice (10, 17).
Prostate cancer mortality: No data was found.
Conclusion: No evidence was found for an association between orange and/or grapefruit juice and prostate cancer.
| Author | Cohort name | Subjects | Years of follow-up | Cases | End point | Consumption of | Relative Risk (RR) | Adjustments |
| 23) Ambrosini GL (2008) | No cohort name. | 1985 blue asbestos-exposed men. (Australia) | Median 12.7 (1990-96 to 2004) | 97? | Prostate cancer incidence | Orange juice | No association with prostate cancer risk (no data shown). | Age, total fruit and vegetable intake, randomly assigned retinol or beta carotene supplement and source fo crocidolite exposure. |
| 17) Stram DO. (2006) | The multiethnic cohort study. | 82,486 African-American, Japanese-American, Native-Hawaiian, Latino and White males aged 45-75. (USA) | 1993-96 to 2001 | 3,922? (1,345 nonlocalized and high grade disease) | prostate cancer risk | Orange/grapefruit juice |
RR = 1.07 (0.97-1.17; P = 0.169) for the highest vs lowest quintile of consumption. Amount specific data (g/1000 kcal*): ≤ 6.3: RR = 1. > 6.3-≤ 16.8: RR = 1.04 (0.94-1.15). > 16.8-≤ 25.9?: RR = 0.98 (0.89-1.09). > 25.9?-≤ 50.0?: RR = 1.02 (0.92-1.12). > 50.0?: RR = 1.07 (0.97-1.17). (P for heterogeneity by ethnic group = 0.156). * = cutpoints for quintiles were defined as 6.3, 16.8, 50.0, and 25.9 respectively! | age, BMI, education and family history of prostate cancer |
| 10) Schuurman AG (1998) | The Netherlands Cohort Study. | 58,279 men aged 55-69 | 6.3 ((1986-1992) | 637? | prostate cancer risk | Processed orange/grapefruit juice | No association: RR = 0.96 (0.89-1.03) per 25 g/day increment. | Age, family history of prostate cancer, socioeconomic status and total vegetables. Additionaly adjusted for total fruits. |