Cruciferous vegetables and all-cause mortality/survival.

Data about cruciferous vegetables was provided by 1 cohort. A significant protective effect was found, but the trend was not significant.

Conclusion: A significant protective effect was found in one cohort of small size. No evidence was found for an association between cruciferous vegetables and mortality.

Author

Cohort name

Subjects

Years of follow-up

Cases

End point

Consumption of

Relative Risk (RR)

Adjustments

28) Genkinger JM. (2004)

The Odyssey Cohort (= CLUE I + CLUE II).

6,151 men and women aged 30-93 from Maryland.
(USA)

1989-2002

910.
of which 307 cancer, and 378 cardiovascular

All cause mortality

Cruciferous vegetables (broccoli, mustard greens, and turnip greens)

HR = 0.78 (0.64-0.96; P = 0.13) for the highest vs lowest quintile of consumption.

Amount specific data (median servings/day):
0.03: HR = 1.
0.12: HR = 0.76 (0.61-0.96).
0.17: HR = 0.82 (0.67-1.01).
0.27: HR = 0.88 (0.71-1.08).
0.53: HR = 0.78 (0.64-0.96).

Low consumption:
HR for the highest 4 fifths compared with the lowest fifth of intake: 0.32 (0.13-0.80).

Age, smoking status, body mass index, cholesterol concentration, and energy.

Marital status and education did not significantly alter the risk estimates and thus were not included in the multivariate models.

18) Hung HC. (2004)

The Nurses' Health Study
&
The Health Professionals' Follow-up Study.

71,910 women (aged 30-55) and
37,725 men (aged 40-75).
(USA)

14
(1984-1998)
(women), and
12
(1986-1998)
(men)

9329? events (1964 cardiovascular, 6584 cancer, and 781 other deaths) in women, and 4957? events (1670 cardiovascular diseases, 2500 cancers, and 787 other deaths) in men

Risk of major chronic disease (cardiovascular disease, cancer, or nontraumatic death)

Cruciferous vegetables (not defined)


Men and women combined	Men	Women
RR = 0.98 (0.93-1.04; P = 0.58) for the highest vs lowest quintile of consumption. Amount specific data (quintiles): 1: RR = 1. 2: RR = 0.97 (0.92-1.02). 3: RR = 0.97 (0.84-1.11). 4: RR = 0.96 (0.84-1.08). 5: RR = 0.98 (0.93-1.04). RR = 0.98 (0.93-1.04) for an increment of 1 serving/day.	RR = 0.95 (No 95% CI; No P-value) for the highest vs lowest quintile of consumption (median servings/day: 1.02 vs 0.14). Amount specific data (quintiles): 1: RR = 1. 2: RR = 0.94. 3: RR = 0.90. 4: RR = 0.89. 5: RR = 0.95. RR = 0.96 (No 95% CI) for an increment of 1 serving/day.	RR = 1.01 (No 95% CI; No P-value) for the highest vs lowest quintile of consumption (median servings/day: 0.94 vs 0.16). Amount specific data (quintiles): 1: RR = 1. 2: RR = 0.99. 3: RR = 1.03. 4: RR = 1.01. 5: RR = 1.01. RR = 1.00 (No 95% CI) for an increment of 1 serving/day.

Total calorie intake, age, smoking status, alcohol use, body mass index, multivitamin and vitamin E supplement use, physical activity, family history of myocardial infarction, family history of colon cancer, personal history of hypertension, personal history of hypercholesterolemia, personal history of diabetes, and (for women only) family history of breast cancer, menopausal status, and use of hormone replacement therapy.

Mortality & Diet.

A systematic review.

Literature review

Relating various aspects of our
diet to mortality & survival.

Cruciferous vegetables and all-cause mortality/survival.

Mortality & Diet.

A systematic review.

Literature review

Relating various aspects of ourdiet to mortality & survival.

Cruciferous vegetables and all-cause mortality/survival.

Relating various aspects of our
diet to mortality & survival.